Publications
*Authors with equal contribution; #Joint-corresponding authors
Huang, Y.*; Schomer, R.*; et al. Metagenome-assembled Genome of Freshwater Hyphomicrobium sp. G-191 enriched from Cedar Swamp, Woods Hole, MA. Genome Resource Announcement. 2024, 13:e0060824. DOI: https://doi.org/10.1128/mra.00608-24
Biggs, B.W.; Price, M.N.; Lai, D.; Escobedo, J.; Fortanel, L.; Huang, Y.Y.; Kim, K.; Trotter, V.V.; Kuehl, J.V.; Lui, L.M.; Chakraborty, R.; Deutschbauer, A.M.; Arkin, A.P. High-throughput protein characterization by complementation using DNA barcoded fragment libraries. Molecular Systems Biology. 2024, 20:1207. DOI: https://doi.org/10.1038/s44320-024-00068-z
Huang, Y.Y.#; Price, M.N.; Hung, A.; Gal-Oz, O.; Tripathi, S.; Smith, C.; Ho, D.; Carion, H.; Deutschbauer, A.M.; Arkin, A.P.# Barcoded overexpression screens in gut Bacteroidales identify genes with roles in carbon utilization and stress resistance. Nature Communications. 2024, 15:6618. DOI: https://doi.org/10.1038/s41467-024-50124-3
Jackson, N.; Belmont, C.R.; Tarlton, N.J.; Allegretti, Y.H.; Sapper, S.A.; Huang, Y.Y.; et al. Genetic predictive factors for non-susceptible phenotypes and multidrug resistance in 3rd generation cephalosporin-resistant uropathogenic E. coli from a multicenter cohort: insights into the phenotypic and genetic basis of co-resistance. mSphere. 2022, 7(6): e00471–22. DOI: https://doi.org/10.1128/msphere.00471-22
Reed, A.D.*; Fletcher, J.R.*; Huang, Y.Y.; Thanissery, R.; Rivera, A.J.; Parsons, A.K.; Stewart, A.K.; Kountz, D.J.; Shen, A.; Balskus, E.P.; Theriot, C.M. The Stickland precursor trans-4-hydroxy-l-proline differentially impacts the metabolism of Clostridioides difficile and commensal Clostridia. mSphere. 2022, 7(2): e00926-21. DOI: https://doi.org/10.1128/msphere.00926-21
Backman, L.R.F.*; Huang, Y.Y.*; Andorfer, M.C.; Gold, B.; Raines, R.T.; Balskus, E.P.; Drennan, C.L. Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-l-proline by a microbial glycyl radical enzyme. eLife. 2020, 9: e51420. DOI: https://doi.org/10.7554/eLife.51420
Huang, Y.Y.; Martínez-del Campo, A.; Balskus, E.P. Anaerobic 4-hydroxyproline utilization: discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity. Gut Microbes. 2018, 9(5): 437–451. DOI: https://doi.org/10.1080/19490976.2018.1435244
Levin, B.J.*; Huang, Y.Y.*; Peck, S.C.; Wei, Y.; Martínez-del Campo, A.; Marks, J.A.; Franzosa, E.A.; Huttenhower, C.; Balskus, E.P. A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline. Science. 2017, 355: eaai8386. DOI: https://doi.org/10.1126/science.aai8386
Caldwell, S.J.; Huang, Y.; Berghuis, A.M. Antibiotic binding drives catalytic activation of aminoglycoside kinase APH(2”)-Ia. Structure. 2016, 24: 935-945.
Ménard, A.; Huang, Y.; Karam, P.; Cosa, G.; Auclair, K. Site-specific fluorescent labelling and oriented immobilization of a triple mutant of CYP3A4 via C64. Bioconjugate Chemistry. 2012, 23: 826-836.
Ménard, A.; Fabra, C.; Huang, Y.; Auclair, K. Type II ligands as chemical auxiliaries to favour enzymatic transformations by P450 2E1. ChemBioChem. 2012, 13: 2527-2536.